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Invited Talks: Prof. Jiří Homola

Prof. Jiří Homola

Head of Photonics Division and Chairman of Department of Optical Sensors
Institute of Photonics and Electronics Academy of Sciences of the Czech Republic Chaberská 57, Prague, Czech Republic

[Jiří Homola]

Jiří Homola (PhD in 1993) is Head of Photonics Division and Chairman of Department of Optical Sensors at the Institute of Photonics and Electronics (formerly Institute of Radio Engineering and Electronics), Prague (Czech Republic). He also is Affiliate Associate Professor at the University of Washington, Seattle (USA).

Dr. Homola leads an interdisciplinary program aiming at research and development of biophotonic devices, in particular optical biosensors. In this field, Dr. Homola holds two patents, edited two 2 books and over 50 research papers in scientific journals and presented over 100 research papers at international conferences.

Dr. Homola is a member of Editorial Boards of Biosensors and Bioelectronics and Sensors and Actuators B (Elsevier) and a member of Permanent Steering Committees of Advanced Study Course on Optical Chemical Sensors and Europt(r)ode Conference Series. He is also Member of NATO CBP Advisory Panel. In 2006 Dr. Homola received Roche Diagnostics Prize for Sensor Technology.

 

Surface Plasmon Resonance Biosensors: Present and Future

Jiří Homola

Institute of Photonics and Electronics Academy of Sciences of the Czech Republic Chaberská 57, Prague, Czech Republic

Over the past two decades, the phenomenon of surface plasmon resonance (SPR) has been increasingly exploited for development of optical sensors. In particular, surface plasmon resonance biosensors have made great strides both in terms of the technology and applications. SPR biosensors opened new horizons for research into biomolecules and their interactions and offered a platform for sensitive, rapid and label-free detection of chemical and biological substances.

This paper reviews the present state of the art in the development of SPR sensor technology, discusses emerging trends, and presents recent results of research into SPR sensors at the Institute of Photonics and Electronics, Prague. The developments discussed in detail include miniature fiber optic SPR sensors for localized measurements, multiple-surface-plasmon spectroscopy for SPR sensor-based analysis of complex samples, and surface plasmon imaging with polarization contrast for highly parallelized observation of biomolecular interactions. Examples of applications of SPR sensors for biomolecular interaction analysis and detection of chemical and biological substances are given. These include study of hybridization properties of modified oligonucleotides for development of antisense drugs, detection of pesticides in the environment, detection of biomarkers for medical diagnostics, and detection of foodborne pathogens and toxins implicated in food safety.

This research was supported by the Czech National Foundation (grant # 202/05/0628) and by the Grant Agency of the Academy of Sciences of the Czech Republic (grant # IAA400500507).

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